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KMID : 1149220170250020193
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Korean Journal of Oriental Medical Prescription
2017 Volume.25 No. 2 p.193 ~ p.207
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Gangjihwan Reduces Body Weight Gain in a ob/ob Female Mice
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Baek Song-Young
Lee Hye-Rim
Park Ju-Hye
Yoon Mi-Chung
Yoon Yoo-Sik
Yang Hee-Jung
Choi Yung-Hyun
Shin Soon-Shik
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Abstract
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Objectives : This study was designed to investigate anti-obesity effects of DF in a ob/ob mouse model.
Methods : Fifteen-week-old ob/ob mice were divided into four groups: a normal lean group given a standard diet, an ob/ob control group given a standard diet, and DF(1) and DF(2) groups given a standard diet with DF(1) (300 mg/kg), and DF(2) (600 mg/kg), respectively. After 10 weeks of treatment, body weight gain, feeding efficiency ratio, blood lipid markers, fat weight and histology were examined.
Results : Body weight gain and fat mass were significantly decreased in DF(1) and DF(2) groups compared with control. The extent of decreases was eminent in DF(2) group. Feeding efficiency ratio were significantly decreased in DF(2) group compared with control. Consistent with their effects on body weight gain and fat mass, circulating concentrations of LDL, total cholesterol, free fatty acid, and insulin were decreased in DF(2) group compared with control. The size of adipocytes were significantly decreased by DF(2) compared with control. Consistent with their effects on body weight gain, hepatic lipid accumulation and liver weights were reduced in DF compared with control.
Conclusions : In conclusion, these results suggest that DF not only decrease feeding efficiency ratio, and blood anti-obesity biomarkers, but also reduce fat mass, contributing to the improvement of obesity. DF also inhibits hepatic lipid accumulation.
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KEYWORD
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Gangjihwan , DF , ob/ob mice , obesity , hepatic lipid accumulation
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